The Second Best Hospital in the Galaxy 2 Review — Prime Video’s offbeat gem just leveled up its lunacy

May 30, 2025 Danial

The Second Best Hospital in the Galaxy quietly joined Prime Video’s lineup last year. It was a hidden gem for fans of adult animation and a good option for anyone waiting for Hazbin Hotel season 2. The show is like Star Trek meets Grey’s Anatomy, wrapped in wild comedy, and mixed with a sharp look at America’s healthcare system. It also takes a surprisingly thoughtful look at anxiety. Now, The Second Best Hospital in the Galaxy 2 takes everything further, with more weird space medicine, smart jokes, and even deeper stories.

Stream The Second Best Hospital in Galaxy Season 2 on Prime Video UK.

The Second Best Hospital in the Galaxy 2 Brings New Chaos and Deeper Drama

In season 1, we followed Dr. Sleech (voiced by Stephanie Hsu) and Dr. Klak (Keke Palmer). They are brilliant alien doctors trying their best in a world ruled by a careless medical giant called UniYum. This company puts profits over patients, leading to disasters. Season 2 shifts the spotlight. This time, we explore Dr. Sleech’s past and the secrets she’s been hiding. Meanwhile, Dr. Klak gets a quieter personal story.

The show uses its sci-fi setting to comment on real-world problems. For example, Sleech’s struggles reflect how some people are pushed out of jobs instead of being supported. Season 2’s satire isn’t as sharp as before, but the unique style still makes big points feel light and fun.

Some Storylines End Too Quickly

One thing that may disappoint fans is how fast some plots wrap up. Season 1 ended with a major twist involving a worm that eats anxiety. But season 2 moves past that quickly. The same happens with Sleech’s secret, which seems huge at first but gets resolved a bit too easily. This makes parts of the story feel rushed.

Even so, the show’s charm isn’t lost. The blend of comedy, heart, and sci-fi still works. And it sets up enough mystery to keep us hoping for season 3, especially with UniYum still lurking in the background.

Supporting Cast Steals the Spotlight

While Sleech and Klak are still the main stars, season 2 gives more time to the side characters, and they shine. Dr. Azel (Sam Smith) brings an odd mix of charm and arrogance that somehow works. Azel’s past drama with Klak is done, but their over-the-top attitude makes scenes funnier.

Nurse Tup (Natasha Lyonne) continues to steal scenes with her dry humor. She’s the kind of character who quietly keeps everything running while roasting everyone around her. Dr. Bognoth (Bowen Yang) finally gets more screen time too, with a hilarious subplot that proves how strong the cast really is.

Some characters, like Dr. Plowp (Kieran Culkin) and Dr. Flam (Maya Rudolph), are harder to connect with because of how alien they are. Still, their jokes land perfectly. The two-headed chief surgeons, the Florks (Gary Anthony Williams and Lennon Parham), also start to grow on you. Their quirky back-and-forth adds to the show’s strange but fun energy.

The Second Best Hospital in the Galaxy 2 Expands the Universe in Clever Ways

This season also dives deeper into the world-building. Did you know the hospital is actually alive? Season 2 answers small questions like this and adds new layers to the setting. The design of the show is still incredible. Every scene is filled with bright colors, wild creatures, and strange gadgets that feel like they belong in this universe.

With its smart jokes, lovable cast, and crazy world, The Second Best Hospital in the Galaxy 2 stays a fun, creative show. It’s a perfect pick for fans of weird comedy, sci-fi, or just something different. And with such a talented voice cast, it’s easy to sit back and enjoy the ride.

Season 2 may not hit every mark, but it still brings all the fun, chaos, and charm that made the first season special. With more story left to tell, here’s hoping for another trip to the galaxy’s second-best (but most entertaining) hospital.